4/21/2023 0 Comments Spy agent green kit![]() Adverse EffectsĪstemizole may decrease the excretion rate of Indocyanine green acid form which could result in a higher serum level.Ītazanavir may decrease the excretion rate of Indocyanine green acid form which could result in a higher serum level.Ītenolol may decrease the excretion rate of Indocyanine green acid form which could result in a higher serum level.Ītorvastatin may decrease the excretion rate of Indocyanine green acid form which could result in a higher serum level.Ītropine may decrease the excretion rate of Indocyanine green acid form which could result in a higher serum level. ClearanceĬlearance of dyes which are removed from the circulation principally by the liver constitutes one of the best methods for evaluating hepatic function. ICG has a half-life of 150 to 180 seconds. ![]() ![]() The dye is excreted in bile in unconjugated form. Protein bindingĩ8% Metabolism Not Available Route of elimination The greater distribution within individual fetal tissues is likely related to ICG's greater transplacental transfer. ICG distribution into the mouse fetus can be enhanced when used concomitantly with OATP or P-glycoprotein inhibitors. It has a peak spectral absorption at about 800 nm. ![]() These characteristics make Indocyanine Green for Injection USP a helpful index of hepatic function. After biliary obstruction, the dye appears in the hepatic lymph, independently of the bile, suggesting that the biliary mucosa is sufficiently intact to prevent diffusion of the dye, though allowing diffusion of bilirubin. Indocyanine Green for Injection USP is taken up from the plasma almost exclusively by the hepatic parenchymal cells and is secreted entirely into the bile. ![]() Indocyanine Green for Injection USP undergoes no significant extrahepatic or enterohepatic circulation simultaneous arterial and venous blood estimations have shown negligible renal, peripheral, lung or cerebro-spinal uptake of the dye. ![]()
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